analysis of klinefelters syndrome

analysis of klinefelters syndromeMany chromosomal abnormalities occur early in farm manpowert and involve the c altogether down chromo roughlys. Klinefelters Syndrome fall(a)s directly into this category. Klinefelters Syndrome is a genetic condition affecting the potent population. The following in exerciseation observes who discover Klinefelters Syndrome and when it was first diagnosed. The etiology or genetic and environ handstal factors of the condition ar discussed as learning abilityspring as complete interpretation of the disability and the clear diagnostic criteria. The affects of Klinefelters Syndrome argon more recognized in vainglorioushood, when it is typically diagnosed. Many Klinefelters patients live out their entire lives without ever knowing they necessitate the condition. Upon conclusion, on that point should be an adequate amount of information that volition give you, the reader, valuable knowledge into the diagnosis and treat manpowert of Klinefelters Syndrome.HistoryKlinefelters Syndrome was first diagnosed in 1942 at the Massachusetts General Hospital in capital of Massachusetts Massachusetts (Schoenstadt, 2006). Dr. Harry Klinefelter was completing his fellowship at the Massachusetts General Hospital when he was designate to work with Dr. Fuller Albright, besides cognize as the father of endocrinology (Bock, 1993 Klinefelter Syndrome, 2006). Dr. Klinefelter came to examine nine adult men that had a uncouth set of symptoms during the course of his fellowship (Klinefelter Syndrome, 2006). Dr. Klinefelter organized a case study that obscure these nine men and their similarities and was encour festerd by Dr.Albright to lead the study (Klinefelter Synrome, 2006). The Journal of Clinical Endocrinologywas published in November of 1942 with the completed case study of these nine mens similarqualities, which Dr. Klinefelter identified as Klinefelters Syndrome (Klinefelter Syndrome,2006). The report written by Dr. Klinefelter on t hese men described them as having testicular dysgenesis, elevated urinary gonadotropins, manly person hypogonadism, azoospermia, and gynecomastia, all of which shed an picture on the under jumped size of the testes, the deprivation of the amount of testoster nonpargonil produced by the testes, and infertility (Schoenstadt, 2006 Visootsak Graham, 2006). These adult male persons also a just enlarged breast and sparse facial hair (Schoenstadt, 2006). Two collections found out fourteen eld after Dr. Klinefelters original description of the syndrome, that the buccal mucosal cells contained an otiose chromatin mass or that the cells were chromatin positive (Klinefelter, 1966). Although the patients were described as having a positive female rouse chromatin, Dr. Klinefelter states that the patients ar phe nonypic males and should never be considered oppositewise (Klinefelter, 1996).Fourteen years after Dr. Klinefelter first diagnosed Klinefelters Syndrome, another case study was performed to nurture understand the distinctions that define the condition (Klinefelter Syndrome, 2006). In 1956, Dr. Joe Hin Tjio and Dr. Albert Lavan took the research make headway to determine the factors that make those men with Klinefelters Syndrome mingled from normal adult males through genetic research (Klinefelter Syndrome, 2006 Schoenstadt, 2006). With the advanced experimental methodology available, Dr. Joe Hin Tjio and Dr. Albert Lavan found that reality had 23 geminates of chromosomes, confirming 46chromosomes, which prior to this term there was thought to be 48 chromosomes (Bock, 1993Klinefelter Syndrome, 2006). This elucidation by Dr. Tjio and Dr. Lavan is the basicfoundation for modern cytogenetics, the study of chromosomes and diseases originating fromnumerical or structural abnormalities in chromosomes (Klinefelter Syndrome, 2006). Dr. Tjio and Dr. Lavan discovered that men with symptoms of Klinefelters Syndrome had an extra sex chromosome that created the chromosomal accord of XXY, which is distinct to the normal male chromosomal arrangement of XY (Klinefelter Syndrome, 2006 Schoenstadt, 2006,). Klinefelter Syndrome was still believed to be an endocrine disorder of unknown etiology at this time (Visootsak Graham, 2006).In 1959, sound three years after Dr. Tjio and Dr. Lavan made their historic discoveries, an English researcher by the name of Dr. Patricia Jacobs and her connect Dr. J. A. Strong published a study supplementing earlier studies (Klinefelter Syndrome, 2006 Noble, 2003). Dr. Jacobs and Dr. Strong found the link between the endocrine disease and the extra X sex chromosome (Noble, 2003). Dr. Jacobs linked forty-s horizontal chromosomes in Klinefelters Syndrome males and determined it to be the X chromosome, which she considered an aneuploidy defined as an unusual number of chromosomes and labeled 47, XXY (Bock, 1993 Klinefelter Syndrome, 2006 Schoenstadt, 2006).The 1970s brought forth a larger question of males b orn with Klinefelters Syndrome (Bock, 1993). During this time doctors began screening newborn male babies for the extra chromosome (Bock, 1993 Visootsak Graham, 2006). The closely signifi set upt of the studies through at this time was sponsored by the National Institute of Child Health and Human nurture(NICHD) whom examined over forty thousand infants for this extra chromosome (Bock, 1993Visootsak Graham, 2006). This study was distinguished for the causal agent that most studies doneprior to the 1970s were slanting and primarily done on adult males in mental institutions and thepenal system (Visootsak Graham, 2006). At this time is when the prevalence of Klinefelters Syndrome was noticed as frequently as one in five hundred to one in one thousand male newborns (Bock, 1993 Visootsak Graham, 2006). Also sight in this study was the reduction in speech and language abilities as well as decreased reading and spelling achievement (Bock, 1993 Visootsak Graham, 2006). a pertinac ious with these disabilities, Klinefelters patients are characterized by an summationd tendency towards fertility, endocrinal, and psychiatric disorders (Noble, 2003). This study demonstrated that most but not all of these males born with the extra chromosome will have these characteristics, and some demonstrate varying degrees of the characteristics (Bock, 1993 Visootsak Graham, 2006). Based on this research it has been found that the extra X chromosome that builds Klinefelters Syndrome is precise common, however, the symptoms and characteristics that are most recognizable are deviate uncommon (Bock, 1993). Most males are not diagnosed as having Klinefelters Syndrome until they r individually adulthood, and many that have the syndrome are never diagnosed as having this chromosomal defect at all (Bock, 1993). single pediatrician at the University of Colorado medical exam School in Denver and the director of the National Institute of Child Health and Human Development (NICHD ) during the major screening research referred to these newborn males as not having Klinefelters Syndrome because of the possibility that the characteristics may not develop into a syndrome (Bock, 1993 Visootsak Graham, 2006).Etiology and Genetic FactorsEvery normal human cell has 46 chromosomes that are made up of 23 pairs (Stewart, 2007). Of these 23 pairs, there are 22 that are exactly the same in both males and females calledautosomes (U.S. National Library of Medicine, 2010). The 23rd pair of sex chromosomes is what makes males and females dissimilar in that the male will have barely one X and Y chromosome whereas the female will have two copies of the X chromosome (Stewart, 2007 U.S. National Library of Medicine, 2010). During the formation of the egg and the sperm, or gametes, the chromosomes are halved through a process called reduction division (Stewart, 2007 The Dorsey, 2009). Cells that carry a single chromosome such as the X or Y chromosome are called monoploidic c ells (The Dorsey, 2009). When the egg and sperm join carrying 23 chromosomes each they create the fertile egg, or zygote, which has two haploid sets of chromosomes (The Dorsey, 2009). in that respectfore, the baby grows two copies of each chromosome, 46 total chromosomes, just like the parents (Stewart, 2007).The extra X in Klinefelter Syndrome is ca utilise from either nondisjunction or anaphase lag. Nondisjunction occurs when the chromosome pairs do not separate as they are intended in the light reflex I or meiosis II stage (Pineyard Zipf, 2003 Stewart, 2007). When this happens there may be a chromosome pair with 24 chromosomes instead of the 23 chromosomes (Stewart, 2007). If this chromosome pair of 24 joins with an egg or sperm with 23 chromosomes thence it cores in a karotype with 47 chromosomes (Stewart, 2007). In this case there will be three copies of chromosomes soma of than the usual two copies of chromosomes (Stewart, 2007). The sperm or egg may donate the extra X c hromosome at conception causing a chromosomal abnormality(Mayo Foundation for medical exam knowledge and Research, 2008 Stewart, 2007). This forms the XXY chromosomal formation, which is diagnosed as Klinefelters Syndrome. At least half of 47, XXY conceptions are spontaneously aborted (Pineyard Zipf, 2003). The chromosomalabnormality is random and not known to be caused by any environmental factors (Genetic Science Learning Center, 2010 Mayo Foundation for Medical Education and Research, 2008 National Institute of Health, 2007).This anomaly happens entirely by chance and is unrelated to family accounting prior to the male minors birth (Mayo Foundation for Medical Education and Research, 2008). This is to say that the male embryos likelihood of macrocosmness born with Klinefelters Syndrome is not increased or decreased by what the parent does or does not do (Mayo Foundation for Medical Education and Research, 2008). Klinefelters Syndrome is not touch by race (Chen, 2010). Thi s is a completely random occurrence of the sex chromosomes not success fully separating during the formation of the egg or the sperm (Genetic Science Learning Center, 2010). Once this occurs the extra chromosome is then copied into every cell of the embryo (Genetics Science Learning Center, 2008). on that point are super noble-minded cases when there may be three or four extra X chromosomes in all copies of the cells known as 48,XXXY or 49, XXXXY (Stewart, 2007). The 49, XXXXY mosaic is also known as Fraccaros Syndrome and is the most rare form of Klinefelters Syndrome (Duenas et al., 2007). This rare chromosomal abnormality results in more exaggerated features of Klinefelters Syndrome (Stewart, 2007). thither are instances where an extra X chromosome is found in only some of the cells (Stewart, 2007). This weed be found as twodifferent chromosomal patterns (Stewart, 2007). One pattern occurs when some cells have 46 chromosomes and some have 47 chromosomes (Stewart, 2007). The ot her pattern is called the mosaic XXY syndrome, or chromosomal mosaicism, and affects approximately six percent ofthese cases, with the most rare cases world the 48, XXXY or the 49, XXXXY, or other arrangements of X chromosomes (Stewart, 2007).The mosaic XXY syndrome occurs only after conception from a error in cell division (Stewart, 2007). Anaphase lag is a result of a gamete lacking a sex chromosome (Klinefelter, 1966). When this chromosome lags it is not incorporated into the new cell during the mitosis stage (Kinefelter, 1996). Anaphase lag is thought to be a reason for the mosaic variations of Klinefelters Syndrome (Klinefelter, 1966).Although the chromosomal abnormality of 49, XXXXY is considered to be a configuration form of Klinefelters Syndrome, it appears to have a very independent, distinct phenotype (Duenas et al., 2007). Males that show the 49, XXXXY chromosomal structure have much more severe clinical features than that of a Klinefelters Syndrome male (Duenas et al. , 2007). This is the most rare of the Klinefelters Syndrome discrepancys and has been reported in over one hundred cases with the frequency being approximately 1 in 85,000 newborn males (Duenas et al., 2007).There have been reports of an even more extreme soma of Klinefelters Syndrome mosaic in newborn males (Duenas et al., 2007). This variant is a 47, XXY/48, XXXY/49, XXXXY mosaicism and has only been reported in three cases accord to a researcher in Mexico (Duenas et al., 2007). This means that the male newborn would have the whole spectrum of XY variations.Another variant that affects only males is the 46, XX chromosomal variation (Bock, 1993). This condition occurs when individuals have two X chromosomes in each cell, but are male in appearance. These individuals have male external geniltalia. These individuals also havesmall, undescended testes possibly along with an urethra opening on the underside of the penis. A small amount of 46, XX Males have external geniltalia that d ont clearly resemble either male or female genitalia. These individuals are typically raised male. Phenotypically, there are three groups of these sex-reversed individuals. The first group includes phenotypically normal XX Males, the second group includes the males with genital ambiguities, and the third group is the veritable hermaphrodites (Bock, 1993).Description of Characteristics or TraitsKlinefelters Syndrome has only one constant physical description and that is the small testicular size (Visootsak Graham, 2003). Boys with Klinefelters Syndrome have variablephenotypic characteristics with no obvious facial dysmorphology (Visootsak Graham, 2003). The front end of gynconemastia, or enlarged breast, and other findings of eunuchoid consistence habits and sparse remains hair vary (Visootsak Graham, 2003). Eunuchoid or eunuchoidism is defined as an abnormal condition in males, characterized by underdeveloped reproductive organs with some female characteristics, such as a hi gher voice or the lack of facial and embody hair that results in the lack of male sex endocrine glands (Eunuchoidism, n.d.). Gonadotropins are produced by glands, such as the pituitary, and can result in sparse body hair when not produced adequately (Gonadotropin, 2010). The medical dictionary states that eunuchoidism is marked by a neediness of sexual development with the persistence of prepubertal characteristics, and oftenhas the strawman of characteristics that are typical of the opposite sex (Eunuchoidism, n.d.). Another likely characteristic is azoospermia (Schoenstadt, 2006 Visootsak Graham, 2006). Azoospermia is defined as having olive-sized or no sperm count (Azoospermia, 2010). testiculardysgenesis, or gonadal dysgenesis, is another characteristic of Klinefelters Syndrome (Schoenstadt, 2006 Visootsak Graham, 2006). Testicular dysgenesis is considered a reproductive system developmental disorder that causes a progressive loss of primordial informant cells, or cells t hat create gametes, in the developing gonads of an embryo (Gonadal dysgenesis, 2010). This gonadal dysgenesis can lead to the extremely hypoplastic, or underdeveloped, and disfunctioning gonads mainly composed of fibrous tissues (Gonadal dysgenesis, 2010).Most infants and churlren with the 47, XXXY chromosomal abnormalities go through normal growth stages. It is not until puberty that the Klinefelters Syndrome characteristics or traits become more prevalent and noticeable (Visootsak Graham, 2003). There is a significant increase in h octonary between the ages of five and eight (Visootsak Graham, 2003). Another characteristic of Klinefelters Syndrome is the elongated length of accouterments and legs (Klinefelter, 1966). There is a decrease in androgen production that causes the secondary sexual characteristics to not fully develop (Visootsak Graham, 2003). An androgen is any substance such as androsterone or testosterone that supports male characteristics (Androgen, n.d.). Typic ally Klinefelters males are infertile (Visootsak Graham, 2003). However, there have been cases of impregnation without the assistance of medical technology (Visootsak Graham, 2003).Autoimmune diseases such as juvenile arthritis can also be present in Klinefelters adolescents. Whereas boys with Klinefelters Syndrome are generally tall with long limbs andremain thin until puberty, they tend to suffer from obesity latter in life. Neurocognitive effects of Klinefelters Syndrome may be more subtle than that of the physical stigmata. Klinefeltersmales have been found to have relative deficits on verbal IQ subtests and have verbal IQ scores around 20 points lower than those of unaffected siblings. There are also deficits in articulation, word finding, phonemic affect, verbal memory, language comprehension, oral expression problems, as well as linguistic processing speed. It seems that the speech/language problems and some motor deficits are most common in Klinefelters males that have an extra X chromosome. Ninety-two percent of individuals with Klinefelters Syndrome confirm difficulty learning to read. seventy percent had reading achievement discrepancies or absolute reading deficits on standardized testing. A group of boys with mental interim and suspicion of fragile X were subject to a genetic screening and the results showed that eight of these boys had Klinefelters Syndrome. Most of the more extreme verbal, visuospatial, and motor skills, such as found in mental retardation and fragile X syndrome are typically spared. However, some boys with Klinefelters Syndrome suffer from poor manual dexterity and are commonly found to be clumsy and below average in sports (Wodrich Tarbox, 2008).There are many different factors that may underlie linguistic and reading problems. One possibility is a dysfunction of the left over(p) hemisphere that may be related to diminished gray matter or a lack of hemispheric asymmetry, or both. It is also workable that executive and f rontal deficits may be a cause (Wodrich Tarbox). There is evidence that language is a fundamental issue for Klinefelters children and this can result in further scholastic issues. This problem seems to manifest as dyslexia as defined by poor reading in the setting of normal intelligence.Klinefelters males have also been observed to have difficulties with arithmetical functions. The deficits in auditory processing and verbal memory are the two key cognitive processes thatunderlie these difficulties. These deficits are also true for normal chromosomal children with dyslexia. The findings are supportive of the concept that defects in frontal systems seem to be caused by a language-based, left frontal-systems problem (Geschwind Dykens, 2004). Adult Klinefelters males have reported to have difficulties with mental flexibility (Wodrich Dykens, 2004). level off with these studies, it should be noted that not all adults that have Klinefelters Syndrome show these classic patterns of verb al deficits that are observed in children (Geschwind Dykens, 2004). However, these findings are not appropriate for all Klinefelters males, many of which complete high prepare and give way on to post-secondary education successfully (Wodrich Tarbox, 2008).Two characteristics that has been falsely associated with Klinefelters males in the past, is sociopathy and criminal behavior. There is, contrary to this belief, less psychiatric problems reported among these individuals. However, there are commonly traits of introversion, unassertiveness, and a paucity or lack of ambition. There are also possible traits of impulsivity and neighborly inappropriateness (Wodrich Tarbox, 2008). A Reiss Profile of Fundamental Goals measurement was used to assess the degrees of which Klinefelters males were motivated in 15 domains (Geschwind Dykens, 2004). The Reiss Profile generates a profile that is based on the motivational sensitivities across the domains of aversive sensations, citizenship, family,curiosity, honor, independence, food, order, physical exercise, rejection, power, sex, socialcontact, vengeance, and social prestige. The Reiss Profile is a well-established psychometricmeasure that is being used more and more to assess people with and without mental retardation(Geschwind Dykes, 2004). The results suggested that the Klinefelters male group was notparticularly motivated by the need for social prestige, independence, or the desire to seek vengeance. This group was also not motivated to avoid physical pain. The general motivator for all the Klinefelters males in this group was curiosity. There were no age effects to this study (Geschwind Dykes, 2004).Characteristics in AdulthoodThere is a persistent deficiency of androgen in adulthood that can result in the loss of libido, decreased muscle quite a little and tone, decreased bone density, a propensity for thromboembolism (an obstruction in a vein or artery from a blood clot), and an increased encounter of mortality from cardiovascular and diabetic complications. A common characteristic for Klinefelters adults is gynecomastia (Wattendorf Muenke, 2005). Gynecomastia involves the risk of developing breast carcinoma. There is 200 times more of a risk for Klinefelters males to develop breast carcinoma than other karyotypically normal individuals. This may be a result of the estradiol (the prominant sex hormone in females) to testosterone ratio being so much higher that karyotypically normal men. Another possibility is that it is caused by the increase of peripheral conversion of testosterone to estradiol (Visootsak Graham, 2006).There are different views as to whether Klinefelters adult males are more aggressive or have a greater chance of psychological issues depending on the resource. One study describes the differences as relative to individual testosterone levels and the age at which they received the diagnosis (Morris, Jackson, Hancock, 2009). Equally, there is an electric shock from the way the diagnosis is reacted to by the Klinefelters male, the family, and friends or peers. The seven major themes that emerged from this study were the diagnosis, the testosterone treatments, healthcare problems, appearance, self-identity, relationships, and school and education. Of the Klinefelters adults studied, 60 % reported clinical levels of anxiety and 34% had clinical levels of depression. The results of this study show that a prolonged lack of testosterone can have far reaching negative effects on the Klinefelters adult (Morris, Jackson, Hancock, 2009). The historical studies show a disturbingly increased risk for psychiatric disturbance, criminality, and mental retardation. However, these results are outdated and extremely questionable given the initial examinations were given to institutionalized populations (Chen, 2010).Differential DiagnosisClassic Klinefelters Syndrome, 47, XXY, cases make up approximately 80-90% of all Klinefelters diagnosis. There are app roximately 6-10% of these cases that are mosaics, which are the cells with 46, XY/47, XXY 46, XY/48, XXXY and 47, XXXY/48, XXXY (Chen, 2010 Visootsak Graham, 2003 Visootsak Graham, 2006). In 5% of the cases there are two X chromosomes without a Y chromosome or 46, XX (Visootsak Graham, 2006). The other cases were karyotypes 48, XXXY, 48, XXYY, 49, XXXXY, and 49, XXXYY (Visootsak Graham, 2003). Approximately 1% of these cases are due to a structurally abnormal X with a normal X and Y chromosome described as kayotypes 47, X,i(Xq)Y and 47, X,del(X)Y (Chen, 2010). Klinefelters Syndrome variants occur much less frequently than the classic 47, XXY chromosomal abnormality (Bock, 1993 Visootsak Graham, 2006).Klinefelter variant 48, XXXY is characterized by being average or tall stature with ocular hyperterlorism, which are widely separated or deep set eyes flat nasal bridge curving of the fifth finger, or clinodactyly. Other characteristics are small penis and testicles with hypergona dotropichypogonadism, which is the absence or decrease in function of the male testes. Theses individuals intelligence quotients range from 40-60. Variant 48, XXYY is characterized by having a tall stature, an eunuchoid habitus with long legs, sparse body hair, small testicles and penis, hypergonadotropic hypogonadism and gynecomastia. These individuals intelligence quotients range from 60-80.Males with variant 49, XXXXY are severely affected. They have smaller than averagehead circumference also known as microcephaly, short stature with ocular hypertelorism, flat nasal bridge, and upslanting palpebral fissures. crack cocaine palates are present along with small geniltalia and a heart defect known as obvious ductus arteriosus. These individuals intelligence quotients range from 20-60. (Visootsak and Graham, 2003).Klinefelters Syndrome 47, XXY, has no major physical signs, which explains why it may go undiagnosed or misdiagnosed throughout an individuals life. Also with no physical signs, it is truly only diagnosed when genetic testing occurs for a multifariousness of unrelated reasons. Klinefelters Syndrome may be diagnosed prenatally or during early childhood, as an adolescent during puberty, or as an adult when there are recognized fertility problems (Bock, 1993). Klinefelters Syndrome can be diagnosed prenatally through amniocentesis or chorionic villus sampling (Bock, 1993). These tests are normally done if the pregnant woman is older than 35, if there is a family history of genetic defects, or when other medical indications exist (Bock, 1993). A pediatrician may suspect a male child as having Klinefelters Syndrome if there are delays in learning to talk or difficulties in reading and writing as well as physical abnormalities during adolescence (Bock, 1993).Treatments and InterventionsAll hope is not lost(p) when it comes to the treatment and interventions of the undesirable traits and characteristics that males diagnosed with Klinefelters Syndrome may display or develop. It is recommended that Klinefelters males have a comprehensive neurodevelopmentalevaluation as soon as they have been diagnosed. A multidisciplinary developmental evaluation can determine the appropriate treatments during babyhood and early childhood. These treatments may include physical therapy, infant simulation programs, and speech therapy (Wattendorf, 2005). If the language difficulties are observe in childhood, then there is more of a possibility for intervention.The language barriers that Klinefelters males may have to bed with can not only affect their academics, it can obstruct their building of social relationships and learning social skills necessary for these relationships. Here is where the Klinefelters child could benefit from a social skills training program. In a social skills training program, the Klinefelters child will be able to practice talking and listening, observing childrens making friends processes, communion of information, attitude s, and beliefs. This will also assist them in proper classroom behavior and playground behavior. Language disabilities and barriers can prevent Klinefelters males from fitting in socially, so this kind of intervention and assistance can benefit the child greatly. Hearing can be an issue if frequent ear infections occur. Hearing test and screens should be done to ensure that a hearing impairment is not a part of the language difficulties. If the Klinefelters child is not communicating effectively with single words by the ages of 18 to 24 months, then consultation with a speech and language pathologist will be very beneficial (KlinefelterSyndrome Information, 2002).Teachers should be informed of the difficulties that a Klinefelters child may be dealingwith in the classroom. A teacher may consider the Klinefelters child to be lazy and daydreaming and a teacher may even forget the child is even in the room. This can result in the Klinefelterschild falling behind and eventually being hel d choke a grade. Under the Public Law 94-142, theIndividuals with Disabilities Education Act, adopted by Congress in 1975, all children withdisabilities have a right to a free, and appropriate public education (Klinefelter SyndromeInformation, 2002).Once the Klinefelters male reaches puberty there is usually an inability to produce a normal amount of testosterone. This along with hypogonadism can result in impaired bone mineral density and skeletal muscle development. Also associated with testosterone deficiency is a decrease in libido and energy (Wattendorf Muenke, 2005). Androgen therapy or Testosterone Treatment should begin by time the Klinefelters male reaches middle school, approximately 12 to 14 years of age, based on the level of pubertal development (Klinefelter Syndrome Information, 2002 Wattendorf Muenke, 2005). Testosterone Treatment will ultimately increase the muscle size and strength, as well as, promoting the growth of body and facial hair. It must be noted that T estosterone Treatments can also bring on psychological changes. It is important to adequately inform the parent(s) and the child of these changes so that they can make the most informed decision (Klinefelter Syndrome Information, 2002). There are different ways to receive Testosterone Treatment and that is through injections, transdermal (patches, gels, or creams), orally, or implantation. The kind of testosterone injection will dependmainly on the dosage used and the country in which you receive the injections. Some injectable testosterone esters are Testosterone enanthate, Testosterone cypionate, Sustanon, Testosterone propionate, Testosterone phenylpropionate, Omnadren, and Aqueous testosterone suspension.Types of transdermal patches are Androderm and Testosterone TTS. Two different kinds oftestosterone gels and creams are Androgel, and Testim. A fewer oral supplements includeMethyltestosterone and Testosterone undecanoate. The last form of Testosterone Treatment is the Subcutan eous testosterone snap, which is delivered by implanting a pellet of pure, crystalline testosterone under the skin of the buttocks or abdomen (Testosterone Types and Delivery, n.d.).Adult males with Klinefelters Syndrome usually develop gynecomastia which predisposes men to breast cancer. Therefore, it is important that Klinefelters males do monthly breast examinations. If gynecomastia causes psychological or physical problems, then possible treatment would be cosmetic surgery to remove the breast tissue (Wattendorf Muenke, 2005). Swerdlow et. al (2005) stated that men with Klinefelter Syndrome have elevated risks of several cancers. Prostate cancer, along with breast cancer was more prevalent. Men with Klinefelter Syndrome are also at a substantially higher risk for non-Hodgkin lymphoma, and possibly lung cancer. Breast cancer risk is higher in 47, XXY mosaics. Adult males may face possible infertility issues due to the lack of testosterone production, but if diagnosed early on, this can be minimized and they will be able to reproduce without outside assistance. unofficialKlinefelter Syndrome is one of the more recently discovered medical syndromes. Klinefelter Syndrome is not one that causes major dysfunctions and is usually only discovered during genetic testing for infertility or during prenatal testing due to maternal age or prior genetic issues within the family. Because Klinefelter Syndrome has not had a lot of research until the last few years, there is no federal funding set aside for this syndrome. Families with sons that are found to be affected by it have no real support system that is knowledgeable of this syndrome and have to research on their own and create resources to fit their situation as none are available in most areas.